S-STEM Scholar Alex Hames's Blog

 CollecTF Database Genome name: Human fecal microbial communities from Cork, Ireland - EM173 BIN ID: 2042536002_2 Ecosystem details: Host associated; human; digestive system; large intestine; fecal Genome name: Human fecal microbial communities from Orebro University Hospital, Sweden - Sample 10368 BIN ID: 2051223000_3 Ecosystem details: Host associated; human; digestive system; large intestine; fecal Genome name:  Human fecal microbial communities from Orebro University Hospital, Sweden - Sample 10368 BIN ID: 2051223000_4 Ecosystem details: Host associated; human; digestive system; large intestine; fecal Resulting transcription factors: CsoR Motif structure: Inverted repeat GC-content: 69.23% Regulatory mode: Activation: 0% Repression: 100% Dual: 0% Not specified: 0% TF conformation:  Monomer: 0% Dimer: 0% Tetramer: 100% Other: 0% Not specified: 0% Binding site type: Motif-associated: 1 Variable-motif-associated: 0 Non-motif-associated: 0 This transcription factor is i...

  Varsite Name: sodium/glucose cotransporter 1 ID number: P13866 Uniprot ID: P13866 Tissue details: Lines the absorptive cells in the small intestine and proximal tubes in the kidney in order to uptake glucose in the cells. Diseases: GGM (Congenital galactose/glucose malabsorption) Tissue specificity: Expressed mainly in the intestine and kidney Cofactors: cellular hexose transport, d efective SLC5A1 causes congenital glucose/galactose malabsorption (GGM), intestinal hexose transport Organs/systems of high level of expression: liver, heart, mouth Organs/system of low level of expression: gonads, brain, pituitary gland I. Three aspects that I am still curious about with my protein are the specifics of the disease that is caused by its mutation- GGM, it's role in other organisms besides humans, and more information on how it can be regulated by drugs and medication. II. A potential research project would be looking into gene manipulation/editing and gene expression of SLC5A1 through ...

SGLT1/Sodium-Glucose Transport 1 Sodium-glucose transport in EBI:  There seem to be no contradictions between the information found about the protein in the EBI database and previous databases at which I have looked at for other assignments. The information about protein function is correct in that the protein transports glucose into the cell through cotransport with sodium at a ratio of 2:1. They also explain that this protein mainly exists in the mammalian kidney along the proximal tubes. The disease related to this protein is also similar to information found in other databases: congenital glucose/galactose malabsorption (GGM). The disease is caused by a variation in the gene (SLC5A1) that is responsible for the production of SGLT1. Symptoms of GGM are extreme dehydration and severe diarrhea. GGM is a recessive disorder that manifests in the first few weeks of life and can lead to death. All of the information found in the EBI database about SGLT1 is very similar to the informat...