S-STEM Scholar Alex Hames's Blog

SGLT1/Sodium-Glucose Transport 1 Sodium-glucose transport in EBI:  There seem to be no contradictions between the information found about the protein in the EBI database and previous databases at which I have looked at for other assignments. The information about protein function is correct in that the protein transports glucose into the cell through cotransport with sodium at a ratio of 2:1. They also explain that this protein mainly exists in the mammalian kidney along the proximal tubes. The disease related to this protein is also similar to information found in other databases: congenital glucose/galactose malabsorption (GGM). The disease is caused by a variation in the gene (SLC5A1) that is responsible for the production of SGLT1. Symptoms of GGM are extreme dehydration and severe diarrhea. GGM is a recessive disorder that manifests in the first few weeks of life and can lead to death. All of the information found in the EBI database about SGLT1 is very similar to the informat...

 

Protein interactors with SGLT1/SLC5A1 (Sodium glucose transport 1) Interactome database: Protein SLC5A1 not found in database String database: EGFR:  Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] SLC2A2:  Solute carrier family 2, facilitated glucose transporter member 2; Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for ...

Summary of protein SGLT1 (sodium glucose transport 1):   Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glu...

  Sodium Glucose Transport 1 (P13866)      The digestive system has a host of biomolecules that perform various functions and aid in digestion and absorption. One of these amazing molecules in the digestive system is the protein, sodium glucose transport 1 (SGLT1), but other names include high infinity sodium-glucose cotransporter, and solute carrier family 5 member 1. SGLT1 is an important protein that mediates and regulates sugars across cell membranes found in humans. The gene that encodes this protein is SLC5A1. These proteins are mainly present in the tissues of the kidney and small intestine. Subcellularly, these proteins can be found mainly in endosomes, apical cell membranes, between cells in cell-cell junctions, and some are found in the extracellular spaces outside of cells through secretion. SGLT1 is used in sodium coupling and is involved in cotransport of sugars and sodium in the kidney proximal tubules. SGLT1 transports sodium and glucose at a ratio of ...