HAMES_DBI.A4

Protein interactors with SGLT1/SLC5A1 (Sodium glucose transport 1)

Interactome database: Protein SLC5A1 not found in database

String database:

EGFR: Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...]

SLC2A2: Solute carrier family 2, facilitated glucose transporter member 2; Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Since the Interactome database does not have the SLC5A1 protein the system, we can't compare the interactive proteins from the two databases. As for the STRING database, the results were experimentally validated. 


Summary: SLC5A1/SGLT1, also known as sodium glucose transport 1, is mainly found in the proximal tubes of the kidneys/small intestine and its purpose is to cotransport sodium out of cell and allow glucose into the cell. The coupling ratio of the sodium to glucose is 2:1 respectively. Within the same subfamily of solute carriers as SGLT1, SLC2A2, also known as SGLT2, helps to facilitate the cotransport the uptake of glucose through the plasma membranes of cells in the digestive system. These two cotransport proteins help regulate the transport of most of the glucose in the kidney and small intestine. The data that they are linked is evidenced by co-expression with a score of 0.070 and co-expressed in other organisms with a score of 0.062. They were also co-mentioned in Pubmed abstracts with a score of 0.872 and mentioned together in other organisms with a score of 0.301. Sodium glucose transport 1 also interacts with the protein EGFR. This protein EGFR is an epidermal growth factor receptor that helps to maintain growth and survival of cells. EGFR activates different reactions in cells by different signals that create phosphorylation. The receptor tyrosine kinase binds ligands of the EGFR family to help this signal to start a cascade of reactions. Through phosphorylation cascades, different reactions occur through different receptors in the cells. As a result, EGFR can react with SGLT1 through regulation of glucose in the bloodstream and the cells along with many other growth factor proteins. EGFR aids in homeostasis along with SGLT1 to maintain glucose uptake and ATP. Both EGFR and SGLT1 are researched heavily for relation to cancers because they are both found in many prostate cancer patients. The link between the two proteins is evidenced by co-expression in other organisms with a score of 0.062. It's also shown in experimental data with a score of 0.270 and co-mentioned in Pubmed abstracts with a score of 0.983. 

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