HAMES_DBI.A5

SGLT1/Sodium-Glucose Transport 1

Sodium-glucose transport in EBI: There seem to be no contradictions between the information found about the protein in the EBI database and previous databases at which I have looked at for other assignments. The information about protein function is correct in that the protein transports glucose into the cell through cotransport with sodium at a ratio of 2:1. They also explain that this protein mainly exists in the mammalian kidney along the proximal tubes. The disease related to this protein is also similar to information found in other databases: congenital glucose/galactose malabsorption (GGM). The disease is caused by a variation in the gene (SLC5A1) that is responsible for the production of SGLT1. Symptoms of GGM are extreme dehydration and severe diarrhea. GGM is a recessive disorder that manifests in the first few weeks of life and can lead to death. All of the information found in the EBI database about SGLT1 is very similar to the information I have gathered through the other databases and there are no discrepancies.

Gene-Disease Associations

Result 1: GIP levels in response to oral glucose tolerance test (120 minutes)

SLC5A1 score: 0.68

Result 2: GLP-1 levels in response to oral glucose tolerance test (120 minutes)

SLC5A1 score: 0.69

Result 3: 1.5-anhydroglucitol levels (EA)

SLC5A1 score: 0.64



Comments

  1. EricaMarch 12, 2022 at 10:08 AM

    Interesting finds. Glad the databases are fairly synced up for your protein-- that is uncommon these days!

    ReplyDelete

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